In the vitamin D3/calcium treated group vs. placebo:1
Over the three-year study period from baseline:2
Following 1 year of treatment with calcium + vitamin D:3
Bischoff-Ferrari’s 2009 meta-analysis demonstrated reductions in nonvertebral fractures with a high dose of vitamin D (482-770 IU/day) compared to lower doses of vitamin D (<400 IU/day)4:
The effect was dose dependent and independent of additional calcium supplementation.4
1. Chapuy MC et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. NEJM 1992; 327(23):1637-42.
2. Dawson-Hughes B et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. NEJM 1997; 337 (10):670-6.
3. Hitz MF et al. Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 year of treatment with calcium and vitamin D. Am J Clin Nutr 2007; 86(1):251-9.
4. Bischoff-Ferrari H et al. Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency. Arch Intern Med. Vol 169 (No. 6) March 23, 2009.