Vitamin D3: The Evidence in Adults
Early French trial – Chapuy
In the vitamin D3/calcium treated group vs. placebo:1
- The number of hip fractures was 43% lower (p=0.043)
- The total number of nonvertebral fractures was 32% lower (p=0.015)
Pivotal US trial – Dawson-Hughes
Over the three-year study period from baseline:2
- Moderately reduced bone loss measured in the femoral neck, spine and total body
- Reduced incidence of nonvertebral fractures
Recent 1 year intervention study – Hitz
Following 1 year of treatment with calcium + vitamin D:3
- Reduced bone turnover and significantly increased BMD in patients ≤70 years of age
- Decreased bone loss in patients aged 70+
- Patients with hip fracture showed the greatest increase in serum 25(OH)D from treatment: 25(OH)D increased from an insufficient concentration of 33nmol/L to 85nmol/L
Meta-analysis - Bischoff-Ferrari
Bischoff-Ferrari’s 2009 meta-analysis demonstrated reductions in nonvertebral fractures with a high dose of vitamin D (482-770 IU/day) compared to lower doses of vitamin D (<400 IU/day)4:
- 29% reduction in nonvertebral fractures in community-dwelling individuals
- 15% reduction in nonvertebral fractures in institutionalised older individuals
The effect was dose dependent and independent of additional calcium supplementation.4
1. Chapuy MC et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. NEJM 1992; 327(23):1637-42.
2. Dawson-Hughes B et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. NEJM 1997; 337 (10):670-6.
3. Hitz MF et al. Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 year of treatment with calcium and vitamin D. Am J Clin Nutr 2007; 86(1):251-9.
4. Bischoff-Ferrari H et al. Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency. Arch Intern Med. Vol 169 (No. 6) March 23, 2009.